Kisspeptin-54
Aliases: KP-54 · Metastin
Last verified: 2026-09-23
The short version
Full-length kisspeptin (54 aa) — a more potent GnRH stimulator than KP-10; clinically studied for reproductive disorders and HSDD. Key fact: Human data are limited: small trials or case-series reports exist, without large randomized studies. Imperial College studies in reproduction and sexual function. Status: in clinical trials. Investigational.
Identity & type
- Molecular type
- peptide
- Origin
- Full-length kisspeptin (54 aa) — a more potent GnRH stimulator than KP-10; clinically studied for reproductive disorders and HSDD.
Mechanism of action
KISS1R agonism on GnRH neurons.
not confirmed in humans
Dosing & routes
Official / clinical context
No approved official document exists for Kisspeptin-54. Any protocols mentioned are to be read as information, not as a recommendation.
Regulator-approved labeling and published study designs — never a recommendation.
Community-reported practice
Trials: IV/SC boluses in nmol ranges. Investigational: a stronger GnRH pulse than KP-10; the community experiments with reproductive-axis "resets".
Unverified self-reports. Not medical advice. Not endorsement.
Expected effects (community)
Investigational: a stronger GnRH pulse than KP-10; the community experiments with reproductive-axis "resets".
Protocol — official vs community
Official / label
No approved protocol exists — clinical-stage investigational agent. Imperial College studies used IV or SC boluses and short infusions in nmol/kg ranges for reproductive and sexual-function endpoints.
Duration: Single-dose or short-infusion study designs; no chronic protocol has been tested.
Kisspeptin-54 was well tolerated across these small studies, which is the strongest statement the human data supports — it was studied in dozens of participants, not thousands.
Community (anecdotal)
Structured protocol data for this entry is coming.
Human evidence
Human data are limited: small trials or case-series reports exist, without large randomized studies. Imperial College studies in reproduction and sexual function.
Preclinical evidence
Imperial College studies in reproduction and sexual function.
Known risks
- Well tolerated.characterized
- Unregulated injectable supply — sterility, purity and accurate dose not assuredtheoretical
Teal: characterized in clinical/labeling contexts. Amber: theoretical or reported outside controlled settings.
Unknowns & evidence gaps
- Long-term human safety
- Optimal dose and pharmacokinetics
Frequently asked questions
References
Systematic references are being expanded; verify sources directly before any decision.