GlyNAC

Metabolism

Components

GlycineModerate evidence NAC (N-acetylcysteine)

Rationale

Two precursors of glutathione — the strongest endogenous antioxidant — whose level declines with age. The combination replenishes both rate-limiting synthesis substrates.

Evidence level

Baylor RCTs in older adults: significant improvements in oxidative stress, glutathione, insulin sensitivity, strength and cognitive measures; effects fade after discontinuation.

Caution

Very safe; NAC occasionally under regulatory scrutiny as a supplement in the EU; GI upset at high doses.