Resveratrol
Aliases: trans-Resveratrol
Last verified: 2026-09-23
The short version
A red-wine polyphenol — it launched the "sirtuin" era of longevity science; human effects are modest and bioavailability low, but it remains popular. Status: research chemical. Legal supplement.
Identity & type
- Molecular type
- mali molekul
- Origin
- A red-wine polyphenol — it launched the "sirtuin" era of longevity science; human effects are modest and bioavailability low, but it remains popular.
Mechanism of action
SIRT1/AMPK modulation (indirect), antioxidant, endothelial function.
Dosing & routes
Official / clinical context
No approved official document exists for Resveratrol. Any protocols mentioned are to be read as information, not as a recommendation.
Regulator-approved labeling and published study designs — never a recommendation.
Community-reported practice
150–1000 mg/day (micronized/trans form, with piperine for absorption). Subtle effects — few feel anything; kept in stacks more for mechanistic logic than experiences.
Unverified self-reports. Not medical advice. Not endorsement.
Expected effects (community)
Subtle effects — few feel anything; kept in stacks more for mechanistic logic than experiences.
Protocol — official vs community
Official / label
Supplement. Human trials used 150 mg–2 g daily; bioavailability is the persistent problem.
- 01500 mg–1 g daily with a fatty meal
Duration: Continuous in trials.
The Sinclair-era mouse data never reproduced in humans; the honest verdict is 'unproven, low risk'.
Community (anecdotal)
500 mg–1 g with fat-containing meals (bioavailability hack).
- Cycle:
- Continuous.
- Break:
- None.
Some longevity clinics dropped it; the community keeps it out of momentum more than data.
Human evidence
Meta-analyses: modest effects on glucose/lipids/blood pressure.
Preclinical evidence
Preclinical literature preceded the clinical trials; details vary by compound.
Known risks
- GI upset at high doses; interactions with anticoagulants.characterized
Teal: characterized in clinical/labeling contexts. Amber: theoretical or reported outside controlled settings.
Unknowns & evidence gaps
- Long-term safety in off-label use
Frequently asked questions
References
Systematic references are being expanded; verify sources directly before any decision.