Urolithin A
Aliases: Mitopure
Last verified: 2026-09-23
The short version
A pomegranate postbiotic (the microbiome makes it from ellagitannins) — activates mitophagy, mitochondrial "recycling". RCT evidence: improved muscle endurance and strength in the elderly.
Identity & type
- Molecular type
- mali molekul
- Origin
- A pomegranate postbiotic (the microbiome makes it from ellagitannins) — activates mitophagy, mitochondrial "recycling".
Mechanism of action
Mitophagy induction → clearance of damaged mitochondria → better cellular energetics.
Dosing & routes
Official / clinical context
Approved drug — indications, dosing and warnings are defined by the official label. 500–1000 mg/day (studied doses).
Regulator-approved labeling and published study designs — never a recommendation.
Community-reported practice
500–1000 mg/day (studied doses). Mitopure users report better muscle endurance and less fatigue after 4–8 weeks; effects modest but consistent in trials.
Unverified self-reports. Not medical advice. Not endorsement.
Expected effects (community)
Mitopure users report better muscle endurance and less fatigue after 4–8 weeks; effects modest but consistent in trials.
Protocol — official vs community
Official / label
Supplement (Mitopure). RCTs used 500–1,000 mg daily (muscle endurance, mitochondrial biomarkers).
- 01500–1,000 mg daily
Duration: Continuous; trial data at 4 months.
One of the few 'longevity supplements' with branded RCT data — modest but real.
Community (anecdotal)
500–1,000 mg daily.
- Cycle:
- Continuous.
- Break:
- None.
Pomegranate-eating gets you nothing if your microbiome doesn't convert it — that's the actual reason the purified form exists.
Human evidence
RCTs (Nature Metabolism 2022; JAMA 2022): +12% muscle endurance, improved mitochondrial markers.
Preclinical evidence
The preclinical phase was completed and submitted to regulators as part of registration; pharmacology and toxicology details are part of the official label.
Known risks
- Excellent tolerability.characterized
Teal: characterized in clinical/labeling contexts. Amber: theoretical or reported outside controlled settings.
Unknowns & evidence gaps
- Long-term safety in off-label use